Hanya ɗaya da ƙwayoyin kansa ke ɓoyewa daga tsarin garkuwar jiki shine ta hanyar samar da shingen shinge na sirara da ake kira glycocalyx. A cikin sabon binciken, masu binciken sun yi nazarin abubuwan da ke cikin wannan shinge tare da ƙudurin da ba a taɓa gani ba, suna gano bayanan da za su iya taimakawa wajen inganta rigakafi na ciwon daji na salula na yanzu.
Kwayoyin ciwon daji sukan samar da glycocalyx tare da manyan matakan mucins na sel, wanda ake tunanin zai taimaka kare kwayoyin cutar kansa daga harin da kwayoyin rigakafi ke kaiwa. Duk da haka, fahimtar jiki game da wannan shinge ya kasance mai iyaka, musamman game da ciwon daji na salula, wanda ya haɗa da cire ƙwayoyin rigakafi daga majiyyaci, gyara su don neman da lalata ciwon daji, sa'an nan kuma mayar da su cikin majiyyaci.
"Mun gano cewa canje-canje a cikin kauri mai ƙanƙanta da nanometer 10 yana shafar ayyukan antitumor na ƙwayoyin rigakafin mu ko kuma ingantattun ƙwayoyin rigakafi," in ji Sangwu Park, ɗalibin da ya kammala karatun digiri a lab ɗin Matthew Paszek a Jami'ar Cornell a ISAB, New York. "Mun yi amfani da wannan bayanin don tsara ƙwayoyin rigakafi waɗanda za su iya wucewa ta cikin glycocalyx, kuma muna fatan za a iya amfani da wannan hanyar don inganta rigakafin rigakafi na zamani." Halittu.
"Lab din mu ya fito da wata dabara mai karfi da ake kira scanning angle internation microscopy (SAIM) don auna glycocalyx na nanosized na kwayoyin cutar kansa," in ji Park. "Wannan dabarar hoto ta ba mu damar fahimtar tsarin dangantakar mucins masu alaƙa da ciwon daji tare da abubuwan da ke cikin biophysical na glycocalyx."
Masu binciken sun ƙirƙiri samfurin salon salula don sarrafa daidaitattun maganganun mucins na sel don yin kwaikwayon glycocalyx na ƙwayoyin cutar kansa. Daga nan sai suka haɗa SAIM tare da tsarin kwayoyin halitta don bincika yadda girman girman, glycosylation, da haɗin gwiwar mucins masu alaƙa da ciwon daji ke shafar kauri na nanoscale barrier. Sun kuma yi nazarin yadda kauri na glycocalyx ke shafar juriyar sel don kai hari ta ƙwayoyin rigakafi.
Nazarin ya nuna cewa kauri na glycocalyx cell ciwon daji yana daya daga cikin manyan sigogin da ke ƙayyade ƙauracewa kwayoyin halitta, kuma cewa ƙwararrun ƙwayoyin rigakafi suna aiki mafi kyau idan glycocalyx ya fi girma.
Bisa ga wannan ilimin, masu bincike sun tsara ƙwayoyin rigakafi tare da enzymes na musamman a saman su wanda ya ba su damar haɗawa da hulɗa tare da glycocalyx. Gwaje-gwaje a matakin salula sun nuna cewa waɗannan ƙwayoyin rigakafi suna iya shawo kan sulke na glycocalyx na ƙwayoyin ciwon daji.
Masu binciken sun yi shirin tantance ko za a iya maimaita waɗannan sakamakon a cikin dakin gwaje-gwaje kuma a ƙarshe a cikin gwaji na asibiti.
Sangwoo Park zai gabatar da wannan binciken (takaice) a lokacin zaman "Regulatory Glycosylation in the Spotlight" ranar Lahadi, Maris 26, 2-3 pm PT, Seattle Convention Center, dakin 608. Tuntuɓi ƙungiyar kafofin watsa labaru don ƙarin bayani ko kyauta kyauta zuwa ga taro.
Nancy D. Lamontagne marubuciya ce ta kimiyya kuma edita a Rubutun Kimiyyar Halittu a Chapel Hill, North Carolina.
Shigar da adireshin imel ɗin ku kuma za mu aiko muku da sabbin labarai, tambayoyi da ƙari kowane mako.
Wani sabon bincike na Pennsylvania ya ba da haske kan yadda ƙwararrun sunadaran suna buɗe ƙullun gungun kwayoyin halitta don amfani.
Mayu shine Watan Fadakarwa da Cututtukan Huntington, don haka bari mu yi la'akari da abin da yake da kuma inda za mu iya magance shi.
Masu bincike na jihar Penn sun gano cewa ligand mai karɓa yana ɗaure zuwa wani nau'in rubutun kuma yana inganta lafiyar gut.
Masu bincike sun nuna cewa abubuwan da ake samu na phospholipid a cikin abincin Yammacin Turai suna ba da gudummawar haɓaka matakan ƙwayoyin cuta na hanji, kumburin tsarin, da samuwar atherosclerotic plaque.
Fassara fifiko "barcode". Rage sabon sunadaran a cikin cututtukan kwakwalwa. Mabuɗin kwayoyin halittar lipid droplet catabolism. Karanta sabbin labarai kan waɗannan batutuwa.
Lokacin aikawa: Mayu-22-2023